We have developed a next iteration miniaturized scope based on the open-source UCLA project. The housing and electronics for the scope have been completely redesigned integrating a new CMOS imaging sensor (Python480),  while maintaining the DAQ of the UCLA miniscope with minor modifications enabling re-use. Weight has been reduced about 2-fold (1.6-1.7 grams including baseplate and GRIN objective). We have added an IMU (inertial measurement unit) and the capability to stimulate optogenetically at a location remote from the image site. Finally, we provide a cross-platform software package (tested in Linux and Windows) that supports up to two miniscopes and a third webcam for behavioral observation.

We will deposit documentation and code on our GitHub repository at:


Status updates will be provided through our Twitter account: